However, our results suggest that a typical astrocytic reaction does not take place in the IC, because we did not find any regulation in marker genes for reactive astrocytes like Vimentin or Glial fibrillary acidic protein (GFAP) which in the case of a thiamine deficiency model were up-regulated (Vemuganti et al., 2006). This evidence concerns the gene GFAP and Thiamine deficiency.