BRAF and melanoma: In the clinical setting, a phase I clinical trial with the selective PI3Kβ-selective inhibitor GSK2636771 in patients with advanced solid tumors with PTEN deficiency is currently ongoing (NCT01458067), and a phase I clinical trial with the PI3Kβ-selective inhibitor (SAR260301) in solid tumors as a single agent and in combination with vemurafenib in BRAF mutant melanoma, has recently been initiated (NCT01673737).