EGFR and esophageal squamous cell carcinoma: Our results demonstrated that although Nimotuzumab alone failed to inhibit ESCC cells growth, we did observe as well that Nimotuzumab dramatically enhanced radiation response of ESCC KYSE30 cell line (the cells with overexpression of EGFR) both in vitro and in vivo, as evidenced by increased radiation-inhibited cell growth and colony formation and radiation-mediated apoptosis.