No 15q25.1 SNPs in CHRNB4 were significantly associated with lung cancer, but a single SNP in the first intron of CHRNA3 did reach statistical significance (rs4243084, OR = 1.33, 95% CI = 1.15-1.53, P = 1.1 × 10−4). This evidence concerns the gene CHRNA3 and lung carcinoma.