Furthermore, we observed that Vpx-mediated SAMHD1 degradation increased infection of DCs with R5-tropic, replication-competent HIV-1NLAD8, as evidenced by 4-fold enhancement of p24 production in the supernatants from infected DCs at 72 hr post-infection (p <0.001) (Figure1E). Here, SAMHD1 is linked to infection.