The reported elevation of IFN-γ could support the previous work of Molloy et al.[5] showing that PBMNC of autistic children produce remarkably high levels of Il-12 and IFN-γ, or express higher than normal levels of mRNA for IFN-γ[39] and the most recent work of Tostes et al.[40] that plasma levels of vasoactive intestinal peptide (VIP), IFN-γ and NO were significantly higher in children with autism, compared to the healthy subjects and that a positive correlation between plasma levels of NO and IFN-γ exists. The gene discussed is IFNG; the disease is autism.