Elevation of Caspase 7 again confirms the contribution of brain cell death and proinflammation in the etiology of autism as previously reported in our recent work in 2011[8], in which Caspase 3 as a pro-apoptotic biomarker was significantly lower in plasma which might indicate its increase in the brain of Saudi autistic patients compared to age- and gender-matched controls. The gene discussed is CASP7; the disease is autism.