In complementary experiments, Agnihotri et al. (2012) showed that shRNA-mediated suppression of endogenous AAG increased sensitivity to TMZ in the GBM cancer stem cell line GBM6, and to methyl methanesulfonate (MMS), a methylator that produces very little O6-meG, in the GBM line T98G. Here, MPG is linked to glioblastoma.