Lucanthone has been reported to inhibit incision at abasic sites by Ape1 in vitro and increase abasic site content in HeLa cells (Mendez et al., 2002), and to increase TMZ sensitivity in human breast cancer cells (Luo and Kelley, 2004) and human GBM cells (Silber and Bobola, unpublished observations). The gene discussed is APEX1; the disease is glioblastoma.