In subsequent experiments, we showed that suppression of Ap endo activity with anti-Ape1 ASO increased killing by the sequence-specific methylator Me-Lex in MGMT-proficient, MGMT-deficient, and MGMT- and mismatch repair-deficient GBM lines (Bobola et al., 2007). The gene discussed is APEX1; the disease is glioblastoma.