SKP1 and viral infectious disease: Given a report by Ye et al. (2011) that SKP1 is induced by TGB3 and is important for virus infection it is possible that the PVX TGB3 protein acts at the ER to redirect such factors to the E3 ligase complex for ubiquitin-proteasome pathway soon after translation as a means to block host immune responses (Ye et al., 2012a).