ANXA1 and Stroke: AnxA1–/– mice have a heightened inflammatory response as displayed by increased leukocyte transmigration (Chatterjee et al., 2005), higher levels of inflammatory markers in a model of localized joint inflammation (Reddy and Standiford, 2010), increased neurological deficit in a stroke model (Gavins et al., 2007) and delayed repair in a model of colitis (Babbin et al., 2008).