In a APP/PS1 mouse model of AD, as soon as 6 months of age, a decrease in the number of oriens-lacunosum moleculare hilar perforant path-associated SRIF-positive interneurons was evidenced in the hippocampus, when no change was demonstrated for 21 additional mRNA markers tested (Ramos et al., 2006). Here, APP is linked to Alzheimer disease.