Postnatally, BMPs play a role in regulating tissue homeostasis in physiological and pathological conditions, such as tissue regeneration (Simic and Vukicevic, 2007; Larman et al., 2009), bone remodeling (Pham et al., 2011), immune function (Passa et al., 2011; Tsalavos et al., 2011), and cancer (Thawani et al., 2010; Buijs et al., 2012). Here, CLN5 is linked to cancer.