PRSS1 and pancreatitis: In addition to PRSS1, CFTR, and SPINK1, the CTRC and CASR genes are additional risk factors that appear to increase risk of pancreatitis in the context of one of three primary susceptibility factors (Larusch and Whitcomb, 2011; Schneider et al., 2011; Rosendahl et al., 2012).