Fig 2A–C shows the flow analysis of leukaemias initiated by blasts sorted for high and low expression of CD10, CD20 or CD34. All populations were able to reconstitute their corresponding population in vivo. The same picture was observed in mice transplanted with cells purified from primary samples: CD20low and CD20high as well as CD34low and CD34high cells (Fig 2D) engrafted and were able to reproduce both populations. This evidence concerns the gene MME and leukemia.