In the present study, we found significant differences between some types of ameloblastomas when using the antibody Ki-67, DA was the tumor that demonstrated the lowest index of proliferation; in contrast, AC displayed the highest index of cell proliferation in comparison with all types of benign ameloblastomas (p <0.05), suggesting a more aggressive biological behavior that is characteristic of malignancy. Here, MKI67 is linked to ameloblastoma.