To evaluate the effect of the alternatively spliced TCRζ 3'-UTR on the expression and regulation of the TCRζ chain and its related genes according to TCRζ 3'-UTR spliceosome characteristics, patients with CML were divided in two subgroups: patients who only expressed the wild type TCRζ 3'-UTR (the WT+AS-CML group), and patients who expressed both TCRζ 3'-UTR forms (the WT+AS+CML group). The gene discussed is CD247; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.