In conclusion, to our knowledge, this is the first study attempting to provide a global gene expression profile of the TCRζ related genes: FcεRIγ, ASF/SF-2 and ZAP-70, and the distribution characteristics of the TCRζ 3'-UTR isoforms in de novo CML and CML-CR patients with TCRζ defective. This evidence concerns the gene ZAP70 and chronic myelogenous leukemia, BCR-ABL1 positive.