CD247 and B-cell chronic lymphocytic leukemia: These data suggest that, in the context of CD3ζ down-regulation, FcεRIγ expression in CML is up-regulated to contribute to TCR signaling transduction in a manner similar to that of the conserved functional ITAM motif, which is a different immune status than that found in CLL, where the FcεRIγ expression level was not up-regulated and was not correlated with the TCRζ expression level[36].