Vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and platelet-derived growth factor (PDGF) are three important pro-angiogenic factors involved in hepatocarcinogenesis, and they participate in the neovascular, invasive, and metastatic potentials of HCC [8-11]. The gene discussed is VEGFA; the disease is hepatocellular carcinoma.