BRCA2 and central nervous system cancer: Furthermore, other recent studies showed that BRCA2 (FANCD1) plays a predominant role in the repair of DNA damage induced by TMZ, and inhibiting BRCA2 sensitize the glioma cell lines to TMZ treatment, suggesting that BRCA2 is also a molecular target for overcoming TMZ resistance (Kondo et al., 2011; Quiros et al., 2011).