In fact, time-resolved fluorescence resonance energy transfer (TR-FRET) performed in HER2-overexpressing ovarian cancer-derived cells (SKOv3) showed that trastuzumab, the HER2 mAb pertuzumab, or EGFR mAb cetuximab disrupted EGFR/HER2 heterodimer formation by 44%, 24%, or 48%, respectively, versus 72% heterodimer disruption by combined trastuzumab and cetuximab and little disruption of heterodimer formation by lapatinib [145]. Here, EGFR is linked to ovarian carcinoma.