Four EDS variants (i.e., arthrochalasia, classic with vascular rupture, cardiac-valvular, and EDS/osteogenesis imperfecta overlap) are caused by dominant or recessive mutations in genes encoding the two chains of collagen type I (COL1A1 and COL1A2) [22–25]. Here, COL1A2 is linked to Ehlers-Danlos syndrome.