Persistence of the suspect of vascular EDS, Loeys-Dietz, or arterial tortuosity syndromes should be further investigated by extensive vascular imaging (i.e., whole-body angio-MRI; or brain angio-MRI plus thoracic and abdominal angio-TC; or heart, abdominal aorta, epiaortic and limb vessels Doppler ultrasound) followed by molecular testing (COL3A1, TGFBR1, TGFBR2, SMAD3, TGFB2, and SLC2A10) in specialized laboratories. This evidence concerns the gene SLC2A10 and Down syndrome.