Inhibition of mTOR has an established antiproliferative effect on pancreatic NETs [88, 89], which led Yao et al. to perform a randomized, phase III study of everolimus versus placebo in 410 patients with advanced, low- or intermediate-grade pancreatic NETs progressing within the preceding 12 months; patients who progressed during the study while on placebo were allowed to crossover to open-label everolimus. Here, MTOR is linked to pancreatic neuroendocrine tumor.