MMP2 and metastatic neoplasm: The expression of matrix metalloproteinase-2 (MMP-2), in patients positive for prostate cells in blood (n = 116), bone marrow aspirates (n = 115), and bone marrow biopsy (n = 132) of men without metastatic disease showed that MMP-2 expression was commonly limited to the edge of the bone marrow fragment (Figure 3(c)).