There have been attempts to combine vitamin C as a potent antioxidant along with vitamin E. Harrison et al. randomized 45 NASH patients to receive vitamin E plus vitamin C (1000 IU/1000 mg/day) versus placebo for 6 months and found that patients receiving the combination treatment demonstrated an improvement in fibrosis but not necroinflammatory activity or serum ALT levels [47]. The gene discussed is GPT; the disease is metabolic dysfunction-associated steatohepatitis.