Mechanisms and factors intervening in the regulation of ACVR1/Alk-2 gene expression are still poorly investigated, although the encoded protein, a type I receptor for BMPs, is involved in fundamental biological processes during embryo development, osteogenic differentiation of progenitor mesenchymal cells [11]–[15], and various pathological conditions including cancer [16], [17]. This evidence concerns the gene ACVR1 and cancer.