Finally, to address the effects of both gain-of-function and loss-of-function of ERBB3 for the growth of rhabdomyosarcoma cells, RD cell transfectants overexpressing ERBB3 or with siRNA-targeted ERBB3 (Fig. 5A) were analyzed using MTT assays measuring the amount of viable cells. Here, ERBB3 is linked to rhabdomyosarcoma.