In a model with ovariectomized female mice, the treatment with E2 reduces left ventricular hypertrophy four and eight weeks after TAC [14].Treatment with 17β-estradiol (E2) attenuates myocyte hypertrophy as well as gene expression of the hypertrophic markers atrial natriuretic peptide (ANP) and beta myosin heavy chain (βMHC) after transverse aortic constriction (TAC) [15]. This evidence concerns the gene NPPA and left ventricular hypertrophy.