While P. yoelii Δp52&p36 breakthrough has not been reported, Labaied et al. previously described a multi-nucleated P. yoelii ‘growth arrested’ Δp52&p36 parasite in a Hepg2-CD81 cell [8], a human hepatoma cell line that promotes the formation of a PVM by P. yoelii[4]. The gene discussed is CD81; the disease is hepatocellular carcinoma.