RAP1A and cancer: As expected, those related to signaling cascades frequently altered in cancer cells were deregulated in our tumor samples, such as stratifin (p53 pathway), heat shock protein β1, 14-3-3 protein β/α, Ras-related protein Rap-1A, stathmin (EGFR, Ras and MAPKK pathway), asporin (TGFβ pathway), 40S ribosomal protein S6 (mTOR pathway), heat shock protein β1 (VEGF pathway), collagen α-1 I (WNT pathway).