ANKRD1 and ischemic cardiomyopathy: Recent studies have also indicated that the Ankrd1 gene is strongly upregulated in the hearts of both hypertrophic animal models [10], [11], [12] and those of heart-failure patients with dilated cardiomyopathy (DCM), ischemic cardiomyopathy (ICM), or arrhythmogenic right ventricular cardiomyopathy (ARVC) [13], [14], [15].