Studies on dysfunctional forms of cTnI associated with hypertrophic cardiomyopathy (HCM) [15]–[17], [19] reveal that some of the disease-associated mutations localize to the C-terminus of cTnI and include residues 145, 162, 183, 199, 203 and 206 (as shown in figure 5C). This evidence concerns the gene TNNI3 and hypertrophic cardiomyopathy.