In lung tissue from both uninfected and 2 d.p.i, DC-SIGN expression was mainly detected on cells with irregular, DC-like morphology located in close proximity of the lumen and large round cells lining the alveolar lumen (Figure 1E and F), suggesting that DC-SIGNhi cells can encounter inhaled viral particles, explaining their infection at the earliest time point. The gene discussed is CD209; the disease is infection.