MTA1 and neoplasm: Alterations of the cellular cytoskeleton organization and polarity are also involved in tumor cell metastasis [31] Therefore, we examined the cytoskeleton structures of the MTA1 siRNA-treated cells by confocal microscopy and found that the ‘feet’ of the MTA1 siRNA-treated cells were shortened and that the cellular polarity was weakened compared to the control cells (Figure 2F-H MTA1: red; nuclei: blue).