APOA1 and myocardial infarction: The existence of anti-apoA-1 IgG in nonautoimmune settings was initially reported in a retrospective study published in 2004, which demonstrated that the prevalence of high levels of anti-apoA-1 IgG was higher in myocardial infarction (MI) patients than in healthy blood donors (21% versus 1%; P = 0.001) [22].