APOA1 and rheumatoid arthritis: Furthermore, in this single-center prospective study, of 133 subjects, the authors demonstrated that RA patients with high levels of anti-apoA-1 IgG had much worse cardiovascular event-free survival (median followup period of 9 years) when compared to patients tested negative for those autoantibodies (43% versus 9%, P = 0.001) [17].