APOA1 and Stroke: In this study, being positive for anti-apoA-1 IgG (with anti-apoA-1 IgG values above the 97.5th centile of anti-apoA-1 IgG values obtained on 140 healthy blood donors) increased the risk of major adverse cardiovascular events (MACE, defined by the occurrence of fatal nonfatal acute coronary syndrome or stroke) by 4-fold (adjusted hazard ratio 4.2; 95% confidence interval (95% CI): 1.5–12.1).