Risk analyses indicated that being positive for anti-apoA-1 antibodies increased the subsequent risk of major adverse cardiovascular events (MACE, consisting of fatal or nonfatal ACS or stroke and hospitalization for acute heart failure) by 4-fold, independently of traditional CV risk factors (OR, 4.3; 95% CI, 1.46–12.6; P = 0.007). Here, APOA1 is linked to stroke disorder.