APOA1 and systemic lupus erythematosus: In a lupus-prone mice model, the presence of anti-apoA-1 antibodies has been shown to be associated with a decrease in the antioxidant properties of HDL related to a decrease in PON-1 activity leading to an increase of proinflammatory reactive oxygen species [50], corroborating the clinical observations reported earlier in humans [13–15, 17, 18].