TLR3 and systemic lupus erythematosus: With respect to SLE, receptors that can recognise viral nucleic acids, such as the endosomally located antiviral TLRs (TLR3, 7/8, and 9) [9–11] the intracellular RIG-I-like receptors (RLRs) [83] and AIM2-like receptors (ALRs) receptor families [84], have been implicated in SLE.