Interestingly, the CGGGG insertion in IRF5 promoter has been associated with a number of autoimmune conditions, such as primary Sjögren's syndrome [131], Multiple sclerosis [132], inflammatory bowel disease and Crohn's disease [133], while the haplotype tagged by rs10488631 seems to be specific in conferring SLE susceptibility [130]. The gene discussed is IRF5; the disease is systemic lupus erythematosus.