Conversely, other studies indicated that the functional avidity of HIV-specific CD8 T cells is not different between patients with progressive or nonprogressive chronic infection or between gag- and other HIV-specific CD8 T cells [150] and also that uncontrolled virus replication seen in progressive HIV infection occurs despite the presence of high-avidity HIV-specific CD8 T-cell responses [142–146, 151, 152]. Here, CD8A is linked to HIV infectious disease.