ICAM1 and rhabdomyosarcoma: In HeLa cells (Figure 3(a)), HRV14 uptake occurs by a dynamin- and presumably clathrin-dependent route [128, 129], whereas endocytosis in ICAM-1 overexpressing rhabdomyosarcoma cells is independent of clathrin, caveolin, flotillin, and lipid rafts [123].