In a study on the carcinogenic process in patients with cholangiocarcinoma arising from pancreaticobiliary malfunction, it was hypothesized that carcinogenesis is involved in chronic inflammation in the biliary epithelium and genetic abnormalities in K-ras, p53, MUC1, and COX2 occurred after chronic inflammation [22, 23]. This evidence concerns the gene TP53 and cholangiocarcinoma.