One person with malignant melanoma showed a serum level of 126 μg/l, which was thought to be due to cell damage and necrosis of tumor sites (Ghanem et al., 2001), even S-100B levels as high as 221 μg/l have been reported in end stage melanoma patients (Martenson et al., 2001). The gene discussed is S100B; the disease is neoplasm.