Poly(ADP-ribose) polymerase (PARP) inhibitors induce apoptosis and tumour CR in EW models, and EWS-FLI1 fusion genes maintain the expression of PARP1, a DNA damage response protein and transcriptional coregulator, thereby enforcing oncogene-dependent sensitivity to PARP-1 inhibition [75]. The gene discussed is EWSR1; the disease is neoplasm.