In OS models, HDAC inhibitors decrease DNA repair capacity [174], sensitising cells to irradiation [175] and doxorubicin [176, 177], facilitate Fas-dependent cell death by increasing Fas expression on tumour cells which die through apoptosis in the presence of FasL (lung) [178], and decrease FLIP expression, a negative regulator of caspase 8 [179]. This evidence concerns the gene FAS and neoplasm.