In addition, due to the multiplicity of EWS-FLI targets and the pathways redundancies, simultaneous inhibition of growth factor receptor and downstream pathways might be useful to overcome some resistance, as well as, targeting different characteristics of the tumour and the environment such as bone microenvironment (Zometa phase III), angiogenesis (bevacizumab phase II), and antitumoural immunity (anti-GD2 humoral or cellular immunity). Here, EWSR1 is linked to neoplasm.