Compared to the controls, we found no change in the distribution of the CD14+CD16+ monocytic subset, whereas the classical CD14++CD16− subset was decreased by 11% (P < 0.001), and the nonclassical CD14dimCD16+ subset was expanded by 4% (P < 0.001) in HF patients and was inversely associated with severe HF (P = 0.015), as assessed by increased end-diastolic dimension (EDD). Here, CD14 is linked to hydrops fetalis.