Methylation of the ATM, HIC1, CDKN1B, PTEN and FHIT genes was not detected in any tumor sample, whereas low frequencies were observed for the DAPK1 (3 samples), CHFR, IGSF4, GSTP1 (2 samples), CDKN2A, RARβ, CASP8, VHL and TP73 (1 sample) genes. The gene discussed is CDKN1B; the disease is neoplasm.