Angiogenesis is crucial for tumor growth and metastasis, and can be stimulated by several regulators including vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), transforming growth factor-β (TGF-β), platelet-derived growth factor (PDGF), interleukin-8, and angiogenin. Here, FGF2 is linked to neoplasm.