Therefore, in this study, we attempted to evaluate the role of VEGF in the C6 glioma-induced migration of BMSCs, whether VEGF upregulates the VCAM-1 expression of BMSCs, the relation between VCAM-1 and the VEGF-induced migration of BMSCs and whether PI3K is involved in the signal transduction of VEGF-induced migration and VCAM-1 upregulation of BMSCs. Here, VEGFA is linked to glioma.