NLRP12 was also recently found to induce inflammasome activation in response to Y. pestis infection, and both NLRP3 and NLRP12 contributed to host defense against Yersinia infection, presumably via induction of caspase-1-dependent IL-1β and IL-18 (Vladimer et al., 2012). This evidence concerns the gene NLRP12 and Yersinia infectious disease.