MAPT and Alzheimer disease: The accumulation of extracellular senile plaques and intracellular aggregates, composed of the β-amyloid peptide, and the intracellular accumulation of neurofibrillary tangles comprising hyperphosphorylated variants of the microtubule-associated protein tau contribute to the progression of AD (Laferla et al., 2007; Benilova et al., 2012; Mandelkow and Mandelkow, 2012).