In animal and cell culture AD/FTLD models expressing AD-associated β-amyloid or FTLD-associated tau, mitochondrial dynamics was demonstrated to be aberrantly altered: abnormal mitochondrial morphology, and altered mitochondrial fission and fusion, as well as decreased mitochondrial motility and increased mitophagy were observed (Correia et al., 2012; Schulz et al., 2012). Here, MAPT is linked to Alzheimer disease.