SKP2 and cancer: Finally, in recent years, SKP2 overexpression has been shown to mediate resistance to TRAIL induced apoptosis (Schuler et al., 2011), and radio- and chemoresistance of human cancer cells (Ishii et al., 2004; Davidovich et al., 2008; Chan et al., 2012; Totary-Jain et al., 2012; Wang et al., 2012b).