TP53 and cancer: In contrast to many other human cancers, p53 mutations in neuroblastoma are rare, occurring in ~3% of cases analyzed to date (Imamura et al., 1993; Komuro et al., 1993; Ohgaki et al., 1993; Vogan et al., 1993; Castresana et al., 1994; Hosoi et al., 1994; Kusafuka et al., 1997; Manhani et al., 1997; Omura-Minamisawa et al., 2001; Tweddle et al., 2001b; Carr-Wilkinson et al., 2010).