MDM2 and neuroblastoma: In addition to p53 mutations, MDM2 amplification, and p14ARF deletion or methylation have also been reported in neuroblastoma tumors and cell lines, most of which were from patients with progressive or relapsed disease and/or post-chemotherapy (Corvi et al., 1995; Omura-Minamisawa et al., 2001; Thompson et al., 2001; Gonzalez-Gomez et al., 2003; Su et al., 2004; Carr et al., 2006; Spitz et al., 2006; Caren et al., 2008; Carr-Wilkinson et al., 2010; Wolf et al., 2010).