This review will focus on three selected MYCN target genes p53, SKP2, and DKK3, which we have previously identified as being directly or indirectly regulated by MYCN (Bell et al., 2007a; Chen et al., 2010), and strategies that are now being or could be employed in the future to target them, particularly in MYCN amplified neuroblastoma. This evidence concerns the gene MYCN and neuroblastoma.