Several studies including our own have found higher expression of SKP2 in the presence of ectopic MYCN, and in MYCN amplified cell lines and tumors (Sugihara et al., 2006; Bell et al., 2007a; Westermann et al., 2007; Chen et al., 2010; Muth et al., 2010; Table 2), suggesting that deregulated SKP2 expression is driven by MYCN to promote neuroblastoma. Here, MYCN is linked to neuroblastoma.