SKP2 and metastatic neoplasm: In addition, amplification of SKP2 at chromosome 5p13 has been reported (Yokoi et al., 2004; Saigusa et al., 2005; Wang et al., 2009; Rose et al., 2011; Li et al., 2012a), and tends to be observed in metastatic tumors whereas overexpression of SKP2 is reported in early cancers (Hershko, 2008).