The restoration of miR-34a and inhibition of miR-380-5p have been shown to reactivate the p53 pathway and inhibit MYCN expression, as well as inhibiting tumor growth in cell lines and orthotopic murine models of neuroblastoma (Wei et al., 2008; Swarbrick et al., 2010; Tivnan et al., 2012). The gene discussed is MYCN; the disease is neuroblastoma.