DKK3 and neuroblastoma: Indeed, in support of this, two recent independent studies have shown that MYCN regulates the expression and secretion of DKK3 in neuroblastoma cells through direct upregulation of the oncogenic miR-17-92 cluster (e.g., miR-92a, -92b, and -19b) which target the 3′UTR of DKK3 (Haug et al., 2011; De Brouwer et al., 2012; Figure 4).