Of interest, although not directly linked to SKP2, bortezomib is shown to induce apoptosis and inhibit cell growth, migration, angiogenesis, and metastasis both in vitro and in murine models of chemosensitive and chemoresistant neuroblastoma (Brignole et al., 2006; Michaelis et al., 2006; Hamner et al., 2007; Valentiner et al., 2009). The gene discussed is SKP2; the disease is neuroblastoma.