A single-nucleotide polymorphism (SNP) in the MDM2 promoter (SNP309T to G) leading to high levels of MDM2 expression has been found in some tumors and is associated with a poor prognostic outcome, including neuroblastoma (Cattelani et al., 2008; Perfumo et al., 2008). This evidence concerns the gene MDM2 and neuroblastoma.