Moreover, observations that inactivation of the p53/MDM2/p14ARF pathway in relapsed neuroblastoma is predominantly due to lesions upstream of p53 combined with the reported therapeutic efficacy of Nutlin-3 in p53 wt multi-drug-resistant preclinical models of neuroblastoma with metastatic burden (Van Maerken et al., 2009a), highly support reactivation of p53 by inhibiting MDM2 as an attractive treatment option for metastatic relapsed neuroblastoma. The gene discussed is TP53; the disease is neuroblastoma.