Several lines of evidence from published literature lend support to the notion that during the process of neuroblastoma progression there is evasion of p53-mediated tumor suppression via inactivation of the p53/MDM2/p14ARF pathway (reviewed by Van Maerken et al., 2009b) as well as a requirement for MYCN amplified neuroblastoma to circumvent MYCN driven apoptosis (reviewed by Hogarty, 2003). This evidence concerns the gene MDM2 and neuroblastoma.