This paradox is observed histologically by a high mitosis-karyorrhexis index, a combined index of both proliferation and apoptosis, in both human MYCN amplified neuroblastoma tumors (Shimada et al., 1995, 1999; Goto et al., 2001; Altungoz et al., 2007) and TH-MYCN transgenic mouse neuroblastoma tumors (Moore et al., 2008). The gene discussed is MYCN; the disease is neuroblastoma.