Melanoma patients also show a specialized subset of immunosuppressive neutrophils in their blood that is induced by serum amyloid A1 (SAA-1), produces the anti-inflammatory cytokine IL-10 and is able to suppress tumour-specific CD8+ T-lymphocyte proliferation in vitro. Intriguingly, SAA-1 also promotes the interaction of these neutrophils with invariant natural killer T cells that decreases their IL-10 production while enhancing IL-12, thereby dampening their immunosuppressive properties, again resulting in the existence of two distinct neutrophil populations with defined functions [74]. This evidence concerns the gene IL10 and neoplasm.