It remains unclear on the definite trigger of ITP, however, the altered pro-inflammation cytokines, especially IL-1β, IL-23, IL-21 and IL-6, may account for the Treg/Th17 imbalance in ITP patients, as they play important role in the differentiation pathway of the two cells [20]. The gene discussed is IL6; the disease is autoimmune thrombocytopenic purpura.