BCL2 and hepatocellular carcinoma: [9]. In vitro cultured cell lines derived from primary HCC tumours that express high levels of the anti-apoptotic Bcl-2 and Bcl-xl were also found to be resistant to paclitaxel [10]. Up-regulation of Bcl-2 family has been implicated in intrinsic gemcitabine resistance in pancreatic and lung cancers [11], [12]. Pancreatic cancer cells that acquired drug resistance to gemcitabine after continuously exposed to gemcitabine had up-regulation of the anti-apoptotic genes such as Bcl-xl and Mcl-1 [13].