SELENOF and colon carcinoma: Our previously published study demonstrated that targeted down-regulation of Sep15 using shRNA (>90% reduction of Sep15 mRNA and protein levels) reversed many of the characteristics typical of cancer cells, including inhibiting anchorage-dependent and anchorage-independent cell growth as well as tumor growth and lung metastasis in mouse colon carcinoma CT-26 but not in mouse Lewis lung carcinoma LLC-1 cells.