Given the recent findings in the SELECT human clinical trial compared to the earlier NPC trial [38], where a reduction in colon cancer risk was observed, it may be beneficial for future studies, if colon biopsies are possible, to include investigations into examining the levels of participants’ Sep15 and GPB-1 expressions, as this may affect their cancer risk, especially for colorectal cancer. The gene discussed is SELENOF; the disease is colonic neoplasm.