Finally, to determine whether ARB effectiveness was limited to Ang II-induced aneurysms, we tested the efficacy of telmisartan in a second murine AAA model, in which aortic aneurysmal degeneration is initiated via intra-aortic infusion of porcine pancreatic elastase (PPE) in normolipidemic C57BL/6J mice, without exposure to exogenous Ang II. This evidence concerns the gene AGT and triple-A syndrome.