Although tissue inhibitor of MMP2, lysyl oxidase and fibronectin 1, enzymes and structural proteins thought to inhibit proteinase activity or stabilize the extracellular matrix [69]–[74], were downregulated in aneurysmal lesions, reciprocal upregulation was not apparent in ARB-treated mice despite the suppressive effects on aneurysm incidence and progression. This evidence concerns the gene LOX and aneurysm.