APOE and achalasia-alacrima syndrome: In contrast, only 7% (1/14) of Ang II-infused ApoE−/− mice treated with irbesartan (50 mg/kg/d in chow) developed AAAs, and none (0/14) of mice treated with telmisartan (10 mg/kg/d in chow) developed an AAA (Fig. 1D).